Seetharaman Shankar, Sosabowski Michael H, Ballinger James R
Department of Pharmacy, Guy's and St Thomas' Hospital, Lambeth Palace Road, London SE1 9EH, UK.
Appl Radiat Isot. 2007 Nov;65(11):1240-3. doi: 10.1016/j.apradiso.2007.02.006. Epub 2007 Mar 5.
Parameters in the preparation of 99mTc-mertiatide (99mTc-MAG3) were investigated to determine the importance of total activity, activity concentration, boiling time, and delay before boiling for the radiochemical purity (RCP) and stability of the product. Satisfactory RCP results (>90%) were obtained over a range of concentrations including a dilute preparation for paediatric use. RCP was not affected by the time between the addition of pertechnetate and boiling, but low RCP (<60%) resulted when the kit was boiled for less than 10 min.
研究了99m锝-美罗他特（99mTc-MAG3）制备过程中的参数，以确定总活度、活度浓度、煮沸时间和煮沸前延迟时间对产品放射化学纯度（RCP）和稳定性的重要性。在包括儿科用稀释制剂在内的一系列浓度范围内均获得了令人满意的RCP结果（>90%）。RCP不受高锝酸盐加入与煮沸之间时间的影响，但试剂盒煮沸时间少于10分钟时会导致RCP较低（<60%）。
