一组HIV阳性长期不进展者中的丙型肝炎病毒（HCV）合并感染：感染HCV基因型对HIV疾病进展可能具有的保护作用。

Hepatitis C virus (HCV) coinfection in a cohort of HIV positive long-term non-progressors: possible protective effect of infecting HCV genotype on HIV disease progression.

作者信息

Morsica Giulia, Bagaglio Sabrina, Ghezzi Silvia, Lodrini Chiara, Vicenzi Elisa, Santagostino Elena, Gringeri Alessandro, Cusini Marco, Carminati Guido, Bianchi Giampaolo, Galli Laura, Lazzarin Adriano, Poli Guido

机构信息

Division of Infectious Diseases, San Raffaele, Scientific Institute, via Stamira d'Ancona n 20, 20127 Milan, Italy.

出版信息

J Clin Virol. 2007 Jun;39(2):82-6. doi: 10.1016/j.jcv.2007.03.007. Epub 2007 Apr 16.

DOI:10.1016/j.jcv.2007.03.007

PMID:17434339

Abstract

BACKGROUND AND OBJECTIVE

Hepatitis C virus (HCV) infection is frequent in HIV-positive subjects. We evaluated the potential impact of HCV coinfection and other determinants on HIV disease progression in a cohort of long-term non-progressors (LTNPs).

STUDY DESIGN

We studied immunological and virological factors in a cohort of 49 LTNPs, 23 of whom progressed during the follow-up (late progressors; LPs).

RESULTS

HCV coinfection was detected in 19/26 LTNPs and 15/23 LPs. Univariate analysis showed that HIV viral load was associated with disease progression (P=0.04), and time-to-event analysis indicated that HCV genotype 1 significantly correlated with LTNP status (P=0.031). At multivariate analysis, HIV viremia at study entry remained independently associated with LTNP status (P=0.049). When the most represented genotypes (1 and 3a) were considered in the model, genotype 3a infection (P=0.034) and gender (P=0.035) emerged as independent variables related to HIV disease progression, whereas HIV viral load disappeared.

CONCLUSIONS

In addition to HIV viremia, coinfection with different HCV genotypes and gender may affect LTNP status.

摘要

背景与目的

丙型肝炎病毒（HCV）感染在HIV阳性患者中很常见。我们评估了HCV合并感染及其他决定因素对一组长期不进展者（LTNP）的HIV疾病进展的潜在影响。

研究设计

我们研究了49名LTNP患者的免疫和病毒学因素，其中23名在随访期间病情进展（晚期进展者；LP）。

结果

在26名LTNP患者中有19名检测到HCV合并感染，在23名LP患者中有15名检测到。单因素分析显示，HIV病毒载量与疾病进展相关（P=0.04），生存分析表明，HCV 1型与LTNP状态显著相关（P=0.031）。多因素分析显示，研究入组时的HIV病毒血症仍与LTNP状态独立相关（P=0.049）。当在模型中考虑最常见的基因型（1型和3a型）时，3a型感染（P=0.034）和性别（P=0.035）成为与HIV疾病进展相关的独立变量，而HIV病毒载量不再相关。