Morsica Giulia, Bagaglio Sabrina, Ghezzi Silvia, Lodrini Chiara, Vicenzi Elisa, Santagostino Elena, Gringeri Alessandro, Cusini Marco, Carminati Guido, Bianchi Giampaolo, Galli Laura, Lazzarin Adriano, Poli Guido
Division of Infectious Diseases, San Raffaele, Scientific Institute, via Stamira d'Ancona n 20, 20127 Milan, Italy.
J Clin Virol. 2007 Jun;39(2):82-6. doi: 10.1016/j.jcv.2007.03.007. Epub 2007 Apr 16.
Hepatitis C virus (HCV) infection is frequent in HIV-positive subjects. We evaluated the potential impact of HCV coinfection and other determinants on HIV disease progression in a cohort of long-term non-progressors (LTNPs).
We studied immunological and virological factors in a cohort of 49 LTNPs, 23 of whom progressed during the follow-up (late progressors; LPs).
HCV coinfection was detected in 19/26 LTNPs and 15/23 LPs. Univariate analysis showed that HIV viral load was associated with disease progression (P=0.04), and time-to-event analysis indicated that HCV genotype 1 significantly correlated with LTNP status (P=0.031). At multivariate analysis, HIV viremia at study entry remained independently associated with LTNP status (P=0.049). When the most represented genotypes (1 and 3a) were considered in the model, genotype 3a infection (P=0.034) and gender (P=0.035) emerged as independent variables related to HIV disease progression, whereas HIV viral load disappeared.
In addition to HIV viremia, coinfection with different HCV genotypes and gender may affect LTNP status.
丙型肝炎病毒（HCV）感染在HIV阳性患者中很常见。我们评估了HCV合并感染及其他决定因素对一组长期不进展者（LTNP）的HIV疾病进展的潜在影响。
我们研究了49名LTNP患者的免疫和病毒学因素，其中23名在随访期间病情进展（晚期进展者；LP）。
在26名LTNP患者中有19名检测到HCV合并感染，在23名LP患者中有15名检测到。单因素分析显示，HIV病毒载量与疾病进展相关（P=0.04），生存分析表明，HCV 1型与LTNP状态显著相关（P=0.031）。多因素分析显示，研究入组时的HIV病毒血症仍与LTNP状态独立相关（P=0.049）。当在模型中考虑最常见的基因型（1型和3a型）时，3a型感染（P=0.034）和性别（P=0.035）成为与HIV疾病进展相关的独立变量，而HIV病毒载量不再相关。
除HIV病毒血症外，不同HCV基因型的合并感染和性别可能影响LTNP状态。
