Sterzik K, Rosenbusch B, Grab D, Lauritzen C
Abt. Frauenheilkunde und Geburtshilfe, Universität Ulm.
Geburtshilfe Frauenheilkd. 1991 Sep;51(9):685-7. doi: 10.1055/s-2007-1023816.
We report on the first pregnancies achieved at our clinic following direct oocyte-sperm-transfer (DOST). Immediately after follicular aspiration, oocytes together with spermatozoa prepared by the swim-up-technique are transferred to the uterus in a manner similar to the embryo transfer following IVF. Our study population consists of 9 patients with bilateral tubal occlusion, accompanied by a male factor in three cases. Up to now, we have achieved four pregnancies, including one twin pregnancy, all occurring, when a male factor was absent. The method described appears promising in terms of efficiency, reduction in the costs and technical procedures during treatment of human infertility.
我们报告了在我们诊所通过直接卵母细胞-精子移植（DOST）实现的首例妊娠情况。卵泡抽吸后，立即将卵母细胞与通过上游技术制备的精子以类似于体外受精后胚胎移植的方式移植到子宫中。我们的研究对象包括9例双侧输卵管阻塞患者，其中3例伴有男性因素。到目前为止，我们已实现了4例妊娠，包括1例双胎妊娠，所有妊娠均在无男性因素的情况下发生。就治疗人类不孕症的效率、成本降低和技术程序而言，所描述的方法似乎很有前景。
