de Vries E, Houterman S, Janssen-Heijnen M L G, Nijsten T, van de Schans S A M, Eggermont A M M, Coebergh J W W
Department of Public Health, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Ann Oncol. 2007 Jun;18(6):1110-6. doi: 10.1093/annonc/mdm087. Epub 2007 Apr 13.
We present survival outcomes of patients registered in the Dutch population-based Eindhoven Cancer Registry (ECR).
Data on patients diagnosed with a melanoma between 1980 and 2002 were obtained from the ECR. Data on vital status up to 1 January 2005 were obtained, up-to-date survival rates were calculated using period analysis. Multivariate analyses were carried out using Cox proportional hazards model.
Ten-year crude survival rates were 82% for women and 60% for men (P < 0.05). Thin melanomas (Breslow thickness <or= 2.0 mm) had 5-year crude survival rates >74%, for melanomas >4.0 mm these rates were <65% (P < 0.05). In the early 1980s, 5-year relative survival rates were 84% and 62% for young (<60 years) women and men, and 66% and 69%, respectively, for the elderly (aged 60+). In the period 2000-2002, these rates had improved to >90% for females and to >72% for males. Multivariate analyses showed increased hazard ratios with increasing age and Breslow thickness, being male, having a melanoma on the trunk or unknown sites and having a nodular melanoma.
Despite the absence of improvements in treatment options for melanoma, survival improved significantly, except for elderly males.
我们呈现了荷兰基于人群的埃因霍温癌症登记处（ECR）登记患者的生存结果。
从ECR获取了1980年至2002年间诊断为黑色素瘤患者的数据。获取了截至2005年1月1日的生命状态数据，使用期间分析计算最新生存率。使用Cox比例风险模型进行多变量分析。
女性的10年粗生存率为82%，男性为60%（P<0.05）。薄黑色素瘤（Breslow厚度≤2.0mm）的5年粗生存率>74%，对于厚度>4.0mm的黑色素瘤，这些比率<65%（P<0.05）。在20世纪80年代初，年轻（<60岁）女性和男性的5年相对生存率分别为84%和62%，老年人（60岁及以上）分别为66%和69%。在2000 - 2002年期间，女性的这些比率提高到>90%，男性提高到>72%。多变量分析显示，随着年龄、Breslow厚度增加、男性、躯干或不明部位有黑色素瘤以及有结节性黑色素瘤，风险比增加。
尽管黑色素瘤的治疗选择没有改善，但除老年男性外，生存率显著提高。
