Santangelo L, Mandarino G, De Biase L, Pesce F, Giacomini P
Institute of Mental and Nervous Diseases, La Sapienza University, Rome, Italy.
Funct Neurol. 1991 Jul-Sep;6(3):275-8.
Pure autonomic failure (PAF) is a rare syndrome characterized by a primitive failure of the autonomic nervous system (ANS). We have studied a 53-year old woman suffering from PAF by using ANS provocative tests investigating the cardiovascular system (standing up test, controlled ventilation, Valsalva manoeuvre, handgrip test, cold pressor test, mental stress test, plasma catecholamine levels), tests investigating the intrinsic ocular innervation (pupil reactivity), and the bladder function (urodynamic tests). Our results have shown abnormalities of all the studied parameters and they have also confirmed that these patients need a multidisciplinary autonomic evaluation to correctly identify the syndrome.
纯自主神经功能衰竭（PAF）是一种罕见的综合征，其特征为自主神经系统（ANS）原发性功能衰竭。我们对一名患有PAF的53岁女性进行了研究，采用了针对心血管系统的自主神经激发试验（直立试验、控制通气、瓦尔萨尔瓦动作、握力试验、冷加压试验、精神应激试验、血浆儿茶酚胺水平）、针对眼内固有神经支配的试验（瞳孔反应性）以及膀胱功能试验（尿动力学试验）。我们的结果显示所有研究参数均存在异常，同时也证实这些患者需要进行多学科自主神经评估以正确识别该综合征。
