Alvarez R D, Potter M E, Soong S J, Gay F L, Hatch K D, Partridge E E, Shingleton H M
Department of Obstetrics and Gynecology, University of Alabama, Birmingham 35233-7333.
Gynecol Oncol. 1991 Nov;43(2):108-12. doi: 10.1016/0090-8258(91)90054-9.
Between 1969 and 1988, 401 patients were treated by radical hysterectomy and pelvic lymphadenectomy for Stage IB cervical carcinoma at the University of Alabama at Birmingham. In multivariate analysis, pathological tumor diameter (P less than 0.0001) and the presence of lymph node metastasis (P = 0.0005) proved to be the dominant two histopathologic features that significantly correlated with overall survival. Although 5-year survival for the overall group was 85%, 5-year survival in patients with lesions greater than 3.0 cm in diameter and with regional nodal metastasis was less than 30%. This discrepancy in survival in surgically treated early-stage cervical cancer patients supports a need for subcategorization by risk factors such as pathologic tumor dimensions and nodal status and for further investigation of alternative neoadjuvant and adjuvant therapies in those early-stage cervical cancer patients deemed at high risk for poor overall survival.
1969年至1988年间，阿拉巴马大学伯明翰分校对401例IB期宫颈癌患者进行了根治性子宫切除术和盆腔淋巴结清扫术。多因素分析显示，病理肿瘤直径（P<0.0001）和淋巴结转移情况（P = 0.0005）是与总生存期显著相关的两个主要组织病理学特征。尽管总体人群的5年生存率为85%，但直径大于3.0 cm且有区域淋巴结转移的患者5年生存率低于30%。手术治疗的早期宫颈癌患者生存情况的这种差异表明，有必要根据病理肿瘤大小和淋巴结状态等危险因素进行亚分类，并对那些被认为总体生存预后不良风险高的早期宫颈癌患者进一步研究替代性新辅助和辅助治疗方法。
