Lin Ling, Wang Jun, Chan Chung-Kit, Chan Sun-On
Department of Anatomy, The Chinese University of Hong Kong, Shatin, NT, Hong Kong.
Neuroreport. 2007 Mar 5;18(4):355-8. doi: 10.1097/WNR.0b013e32802b70e2.
CD44 has been shown to be involved in midline crossing and the generation of ipsilateral projections in the mouse optic chiasm. To determine whether these functions involve hyaluronan, the major ligand of CD44, we examined localization of hyaluronan in the mouse optic pathway. Hyaluronan was deposited mainly in vitreal regions of the retina and the optic disk. In ventral diencephalon, it was localized largely on the chiasmatic neurons that project processes to the chiasmatic midline and the optic tract. Colocalization of hyaluronan and CD44 was observed only in the midline but not lateral domains of the chiasmatic neurons, suggesting a hyaluronan/CD44-mediated mechanism that controls axon routing at the midline but not at the optic tract and the retina.
已表明CD44参与小鼠视交叉中的中线交叉和同侧投射的形成。为了确定这些功能是否涉及CD44的主要配体透明质酸，我们检测了透明质酸在小鼠视觉通路中的定位。透明质酸主要沉积在视网膜和视盘的玻璃体区域。在腹侧间脑，它主要定位于向视交叉中线和视束投射突起的视交叉神经元上。仅在视交叉神经元的中线而非外侧区域观察到透明质酸与CD44的共定位，这表明存在一种透明质酸/CD44介导的机制，该机制控制中线处而非视束和视网膜处的轴突导向。
