Mohamad Mohamad Jaffer, Mohammad Mukhallad A, Karayyem Mohamad, Hairi Aktham, Hader Adulfatah Al
Department of Physiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Neuro Endocrinol Lett. 2007 Apr;28(2):182-6.
To compare the serum levels of total testosterone(TT), free testosterone (FT), estradiol, sex hormone binding globulin (SHBG), and androstenedione (AS) in patients with acute myocardial infarction (AMI) at the time of hospitalization, patients with old myocardial infarction (OMI), and patients with normal coronary arteries (NC) admitted for diagnostic coronary angiography.
Serum sex hormones and lipid profile were measured in 79 male patients; 30 patients with AMI, 21 patient with OMI and 28 patients with NC. Ages ranged from 33-68 years. Androstenedione, estrogen, both total and free testosterone levels were quantified using coat-a-count radioimmunoassay kits. Sex hormone binding globulin was analyzed using immunoradiometric assay (IRMA)-count kits.
The levels of serum estradiol in the AMI were significantly higher and serum levels of TT, FT, and SHBG were significantly lower in AMI than in OMI and NC but there was no difference found for the levels of AS in all groups. Estradiol level was also higher in OMI than in control group but no significant changes found for other sex hormones in OMI and control group. Also triglyceride, high density and low density lipoprotein in AMI were significantly different from that in OMI and control groups.
Serum estradiol and low density lipoprotein levels are increased but TT, FT and SHBG levels are decreased in men with AMI compared with patients with NC.
比较急性心肌梗死（AMI）患者住院时、陈旧性心肌梗死（OMI）患者以及因诊断性冠状动脉造影而入院的冠状动脉正常（NC）患者的血清总睾酮（TT）、游离睾酮（FT）、雌二醇、性激素结合球蛋白（SHBG）和雄烯二酮（AS）水平。
对79例男性患者进行血清性激素和血脂谱检测；其中30例AMI患者、21例OMI患者和28例NC患者。年龄范围为33 - 68岁。使用 Coat-a-Count放射免疫分析试剂盒对雄烯二酮、雌激素、总睾酮和游离睾酮水平进行定量。使用免疫放射分析（IRMA）计数试剂盒分析性激素结合球蛋白。
AMI患者血清雌二醇水平显著升高，AMI患者血清TT、FT和SHBG水平显著低于OMI患者和NC患者，但所有组的AS水平无差异。OMI患者的雌二醇水平也高于对照组，但OMI患者和对照组的其他性激素水平无显著变化。此外，AMI患者的甘油三酯、高密度脂蛋白和低密度脂蛋白与OMI患者和对照组也有显著差异。
与NC患者相比，AMI男性患者血清雌二醇和低密度脂蛋白水平升高，但TT、FT和SHBG水平降低。
