Chang Howard Y
Program in Epithelial Biology, Stanford University, Stanford, California 94305, USA.
J Invest Dermatol. 2007 May;127(5):994-5. doi: 10.1038/sj.jid.5700636.
One of the striking regional variations in skin is its pigmentation. Yamaguchi et al. further dissect the mechanism of regional pigmentation by assessing the effects of dickkopf 1 (DKK1), an antagonist of the Wnt pathway produced in lightly pigmented skin, on melanocyte gene expression. The results provide a plethora of candidate genes that may mediate DKK1's inhibitory effects on melanocyte function.
皮肤显著的区域差异之一在于其色素沉着。山口等人通过评估在色素较浅的皮肤中产生的Wnt信号通路拮抗剂Dickkopf 1（DKK1）对黑素细胞基因表达的影响，进一步剖析了区域色素沉着的机制。研究结果提供了大量可能介导DKK1对黑素细胞功能抑制作用的候选基因。
