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沉默的表皮生长因子受体有助于伤口愈合。

The dumb ErbB receptor helps healing.

作者信息

Poumay Yves G

机构信息

Cell and Tissue Laboratory, Faculty of Medicine, University of Namur, Namur, Belgium.

出版信息

J Invest Dermatol. 2007 May;127(5):995-7. doi: 10.1038/sj.jid.5700685.

Abstract

ErbB3 receptor is a member of the epidermal growth factor (EGF) receptor (ErbB1) family. Okwueze et al. have transfected this receptor in a pig model of wounds and demonstrate that it accelerates the resurfacing of the wounds when combined with epiregulin or heparin-binding EGF. Currently, only hypotheses can be proposed to explain the observations.

摘要

ErbB3受体是表皮生长因子(EGF)受体(ErbB1)家族的成员。Okwueze等人已在猪伤口模型中转入该受体,并证明当与表皮调节素或肝素结合型EGF联合使用时,它能加速伤口的再上皮化。目前,只能提出一些假设来解释这些观察结果。

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