Tomich Mladen, Planet Paul J, Figurski David H
Department of Microbiology, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York 10032, USA.
Nat Rev Microbiol. 2007 May;5(5):363-75. doi: 10.1038/nrmicro1636.
The Tad (tight adherence) macromolecular transport system, which is present in many bacterial and archaeal species, represents an ancient and major new subtype of type II secretion. The tad genes are present on a genomic island named the widespread colonization island (WCI), and encode the machinery that is required for the assembly of adhesive Flp (fimbrial low-molecular-weight protein) pili. The tad genes are essential for biofilm formation, colonization and pathogenesis in the genera Aggregatibacter (Actinobacillus), Haemophilus, Pasteurella, Pseudomonas, Yersinia, Caulobacter and perhaps others. Here we review the structure, function and evolution of the Tad secretion system.
紧密黏附（Tad）大分子转运系统存在于许多细菌和古菌物种中，是II型分泌的一种古老且重要的新亚型。tad基因位于一个名为广泛定植岛（WCI）的基因组岛上，编码组装黏附性菌毛样低分子量蛋白（Flp）菌毛所需的机制。tad基因对于聚集杆菌属（放线杆菌属）、嗜血杆菌属、巴斯德菌属、假单胞菌属、耶尔森菌属、柄杆菌属等菌属的生物膜形成、定植和致病作用至关重要。在此，我们综述Tad分泌系统的结构、功能及进化。
