Garenfeld W, Wilting I
Tijdschr Psychiatr. 2007;49(4):251-5.
Phenothiazines can give rise to serious and sometimes irreversible dermatological and oculotoxic side effects. These effects can take the form of photosensitivity, grey-purple discoloration and hyperpigmentation of the skin and hyperpigmentation of the conjunctiva, cornea, lens, retina, choroidea and macula. Involvement of the retina or macula can lead to impaired vision, blurred vision, disturbed colour perception and night blindness. We describe the mechanisms that are currently believed to underlie these side-effects. We advise annual ophthalmic monitoring of patients receiving long-term treatment with phenothiazianes.
吩噻嗪类药物可引起严重且有时不可逆的皮肤和眼毒性副作用。这些副作用表现为光敏性、皮肤灰紫色变色和色素沉着以及结膜、角膜、晶状体、视网膜、脉络膜和黄斑色素沉着。视网膜或黄斑受累可导致视力受损、视力模糊、色觉障碍和夜盲。我们描述了目前认为导致这些副作用的机制。我们建议对接受吩噻嗪类药物长期治疗的患者进行年度眼科监测。
