Amaral Leonard, Engi Helga, Viveiros Miguel, Molnar Joseph
Unit of Mycobacteriology, UPMM, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, 1349-088 Lisboa, Portugal.
In Vivo. 2007 Mar-Apr;21(2):237-44.
Bacteria and cancer cells develop resistance to more than one agent as a consequence of being exposed to ineffective levels of the agent for a prolonged period of time. The resistance of these cells is mediated by over-expressed efflux pumps that have the ability to extrude a large variety of unrelated chemicals. This review discusses the main types of multidrug resistant (MDR) efflux systems of bacteria and cancer cells, and shows the similarity of specific efflux systems between them with respect to given agents that inhibit efflux, thus rendering these cells once more susceptible to agents to which they had developed MDR.
由于长时间暴露于无效剂量的药物中，细菌和癌细胞会对不止一种药物产生耐药性。这些细胞的耐药性是由过度表达的外排泵介导的，这些外排泵能够排出多种不相关的化学物质。本文综述了细菌和癌细胞多药耐药（MDR）外排系统的主要类型，并展示了它们特定外排系统在抑制外排的特定药物方面的相似性，从而使这些细胞再次易于受到它们已产生MDR的药物的影响。
