硫利达嗪对实验性皮肤葡萄球菌感染的影响。
Effect of thioridazine on experimental cutaneous staphylococcal infections.
作者信息
Hahn Beth L, Sohnle Peter G
机构信息
Research Service/151, VA Medical Center, Milwaukee, WI, U.S.A.
出版信息
In Vivo. 2014 Jan-Feb;28(1):33-8.
BACKGROUND
Some non-antibiotic drugs, such as the phenothiazine antipsychotic agents, may have antimicrobial activity.
MATERIALS AND METHODS
We sought to determine the in vivo antimicrobial effects of the phenothiazine thioridazine in two mouse models of Staphylococcus aureus skin infection.
RESULTS
Thioridazine significantly suppressed dissemination from skin to spleen and kidney after inoculation of the skin surface. However, the drug did not affect infection parameters in the skin itself. Thioridazine did suppress the size of abscesses produced when the bacteria were injected intradermally. On the other hand, using the cutaneous abscess model we were not able to demonstrate synergistic activity between thioridazine and the β-lactam drug cefazolin against methicillin-resistant S. aureus, as previously demonstrated in vitro.
CONCLUSION
The phenothiazine drug thioridazine has in vivo antimicrobial activity against certain S. aureus skin infections, although the previously-demonstrated reversal of methicillin resistance by this agent may not be readily evident in vivo.
背景
一些非抗生素药物，如吩噻嗪类抗精神病药物，可能具有抗菌活性。
材料与方法
我们试图在两种金黄色葡萄球菌皮肤感染小鼠模型中确定吩噻嗪类药物硫利达嗪的体内抗菌效果。
结果
在皮肤表面接种后，硫利达嗪显著抑制了细菌从皮肤扩散至脾脏和肾脏。然而，该药物对皮肤本身的感染参数没有影响。硫利达嗪确实抑制了皮内注射细菌时产生的脓肿大小。另一方面，使用皮肤脓肿模型，我们未能证明硫利达嗪与β-内酰胺类药物头孢唑林对耐甲氧西林金黄色葡萄球菌具有协同活性，而此前在体外实验中已得到证明。
结论
吩噻嗪类药物硫利达嗪对某些金黄色葡萄球菌皮肤感染具有体内抗菌活性，尽管该药物先前证明的对甲氧西林耐药性的逆转在体内可能并不明显。
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