结直肠癌患者术前而非术后的全身炎症反应与生存率相关。
Preoperative but not postoperative systemic inflammatory response correlates with survival in colorectal cancer.
作者信息
Crozier J E M, McKee R F, McArdle C S, Angerson W J, Anderson J H, Horgan P G, McMillan D C
机构信息
University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK.
出版信息
Br J Surg. 2007 Aug;94(8):1028-32. doi: 10.1002/bjs.5706.
BACKGROUND
The aim of the present study was to evaluate the relationship between the preoperative and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for colorectal cancer.
METHODS
One hundred and eighty patients with colorectal cancer were studied. Circulating concentrations of C-reactive protein (CRP) were measured before surgery and in the immediate postoperative period.
RESULTS
The peak in CRP concentration occurred on day 2 (P < 0.001). During the course of the study 59 patients died, 30 from cancer and 29 from intercurrent disease. Day 2 CRP concentrations were dichotomized. In univariable analysis, advanced tumour node metastasis stage (P = 0.002), a raised preoperative CRP level (P < 0.001) and the presence of hypoalbuminaemia (P = 0.043) were associated with poorer cancer-specific survival.
CONCLUSION
Preoperative but not postoperative CRP concentrations are associated with poor tumour-specific survival in patients undergoing potentially curative resection for colorectal cancer.
背景
本研究的目的是评估接受结直肠癌潜在根治性切除手术患者术前和术后全身炎症反应与生存率之间的关系。
方法
对180例结直肠癌患者进行研究。在手术前和术后即刻测量循环中C反应蛋白（CRP）的浓度。
结果
CRP浓度在术后第2天达到峰值（P < 0.001）。在研究过程中，59例患者死亡，30例死于癌症，29例死于并发疾病。将术后第2天的CRP浓度进行二分法分析。在单变量分析中，肿瘤淋巴结转移晚期（P = 0.002）、术前CRP水平升高（P < 0.001）和存在低白蛋白血症（P = 0.043）与较差的癌症特异性生存率相关。
结论
在接受结直肠癌潜在根治性切除手术的患者中，术前而非术后的CRP浓度与较差的肿瘤特异性生存率相关。
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