Canna K, Hilmy M, McMillan D C, Smith G W, McKee R F, McArdle C S, McNicol A-M
University Department of Surgery, Royal Infirmary, Glasgow, UK.
Colorectal Dis. 2008 Sep;10(7):663-7. doi: 10.1111/j.1463-1318.2007.01416.x. Epub 2007 Nov 12.
The aim of the present study was to examine the relationship between Ki-67, C-reactive protein and cancer-specific survival in patients undergoing resection for colorectal cancer.
One hundred and forty-seven patients undergoing potentially curative resection for colorectal cancer had preoperative C-reactive protein concentrations and tumour Ki-67 labelling index measured.
On univariate analysis, age (P < 0.001), Dukes stage (P < 0.001), C-reactive protein (P < 0.001) and expression of Ki-67 (< 0.01) were associated with poorer cancer-specific survival. Ki-67 labelling index and C-reactive protein were correlated (r(s) = 0.172, P = 0.037). On multivariate analysis, age (HR 1.96, 95% CI 1.26-3.04, P = 0.003), Dukes stage (HR 4.38, 95% CI 2.11-9.09, P < 0.001) and C-reactive protein (HR 4.09, 95% CI 2.04-8.24, P < 0.001) retained significance.
Increased tumour proliferation is associated with a systemic inflammatory response and poor cancer-specific survival in patients undergoing potentially curative surgery for colorectal cancer.
本研究旨在探讨接受结直肠癌切除术患者的Ki-67、C反应蛋白与癌症特异性生存率之间的关系。
对147例接受结直肠癌根治性切除术的患者术前测量C反应蛋白浓度和肿瘤Ki-67标记指数。
单因素分析显示，年龄（P < 0.001）、Dukes分期（P < 0.001）、C反应蛋白（P < 0.001）和Ki-67表达（P < 0.01）与较差的癌症特异性生存率相关。Ki-67标记指数与C反应蛋白相关（r(s)=0.172，P = 0.037）。多因素分析显示，年龄（HR 1.96，95%CI 1.26 - 3.04，P = 0.003）、Dukes分期（HR 4.38，95%CI 2.11 - 9.09，P < 0.001）和C反应蛋白（HR 4.09，95%CI 2.04 - 8.24，P < 0.001）仍具有显著性。
在接受结直肠癌根治性手术的患者中，肿瘤增殖增加与全身炎症反应及较差的癌症特异性生存率相关。
