简化的狂犬病暴露前疫苗接种程序的免疫原性研究
Immunogenicity study of abbreviated rabies preexposure vaccination schedules.
作者信息
Khawplod Pakamatz, Wilde Henry, Benjavongkulchai Maneerat, Sriaroon Chakrapol, Chomchey Pranee
机构信息
Queen Saovabha Memorial Institute of the Thai Red Cross Society and the Department of Medicine, King Chulalongkorn University Hospital, Bangkok, Thailand.
出版信息
J Travel Med. 2007 May-Jun;14(3):173-6. doi: 10.1111/j.1708-8305.2007.00120.x.
OBJECTIVE
To evaluate abbreviated preexposure rabies vaccination schedules that would reduce cost and shorten time required for completion.
METHOD
A random prospective immunogenicity study, using a group of 96 volunteer preclinical veterinary students, primary school children, and hospital-based health care workers. They were divided into six groups and administered abbreviated schedules of preexposure tissue culture rabies vaccines. Neutralizing antibodies were determined on days 0 and 360, and following boosters on days 367 and 374.
RESULTS
All subjects, including one group that received only 0.1 mL intradermally at two sites on one day, had detectable neutralizing antibody titers 1 year later and responded with an accelerated antibody response when given booster injections.
CONCLUSION
It might be possible to develop a 1-week and even one clinic visit preexposure vaccine schedule that would provide at least 1 year of immune memory.
目的
评估可降低成本并缩短完成所需时间的简化暴露前狂犬病疫苗接种方案。
方法
一项随机前瞻性免疫原性研究，使用了一组96名临床前兽医专业学生、小学生和医院医护人员志愿者。他们被分为六组，并接种简化的暴露前组织培养狂犬病疫苗方案。在第0天和第360天以及在第367天和第374天进行加强免疫后测定中和抗体。
结果
所有受试者，包括一组仅在一天内在两个部位皮内注射0.1 mL的受试者，在1年后均具有可检测到的中和抗体滴度，并且在接受加强注射时抗体反应加速。
结论
有可能制定一种1周甚至只需一次门诊就诊的暴露前疫苗接种方案，该方案可提供至少1年的免疫记忆。
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