Campese V M, Parise M, Karubian F, Bigazzi R
Department of Medicine, University of Southern California Medical Center, Los Angeles 90033.
Hypertension. 1991 Dec;18(6):805-12. doi: 10.1161/01.hyp.18.6.805.
African-Americans with essential hypertension are more prone to the development of renal failure and are frequently salt-sensitive as well. Because alterations of intrarenal hemodynamics are important in the progression of renal disease and because salt-sensitive animal models with hypertension manifest a greater propensity to develop glomerulosclerosis in association with a rise in glomerular capillary pressure, we tested whether the renal hemodynamic adaptation to high dietary Na+ intake differs in salt-sensitive and salt-resistant hypertensive patients. We studied 17 black and nine white patients with essential hypertension who were placed on a low Na+ diet (20 meq/day) for 9 days, followed by a high Na+ diet (200 meq/day) for 14 days. During the last 4 days of each diet regimen, they received 30 mg/day of slow-release nifedipine. Eleven blacks were salt-sensitive, and all whites were salt-resistant. During the low Na+ diet period, salt-sensitive and salt-resistant patients had similar mean arterial pressure, glomerular filtration rate, effective renal plasma flow, and filtration fraction.(ABSTRACT TRUNCATED AT 250 WORDS)
患有原发性高血压的非裔美国人更容易出现肾衰竭，并且通常也对盐敏感。由于肾内血流动力学改变在肾脏疾病进展中很重要，而且盐敏感型高血压动物模型在肾小球毛细血管压力升高时更易发生肾小球硬化，因此我们测试了盐敏感型和盐抵抗型高血压患者对高钠饮食摄入的肾血流动力学适应性是否存在差异。我们研究了17名黑人和9名白人原发性高血压患者，他们先接受9天的低钠饮食（20毫当量/天），然后接受14天的高钠饮食（200毫当量/天）。在每种饮食方案的最后4天，他们每天服用30毫克缓释硝苯地平。11名黑人对盐敏感，所有白人对盐抵抗。在低钠饮食期间，盐敏感型和盐抵抗型患者的平均动脉压、肾小球滤过率、有效肾血浆流量和滤过分数相似。（摘要截短于250字）
