Compston Juliet E
University of Cambridge School of Clinical Medicine, and Addenbrooke's Hospital, Box 157, Cambridge CB2 2QQ, UK.
Curr Rheumatol Rep. 2007 Apr;9(1):78-84. doi: 10.1007/s11926-007-0026-x.
Glucocorticoid-induced osteoporosis is a common but still relatively neglected problem, with a low level of awareness among primary and secondary care physicians. Fractures appear early after initiation of treatment, and effective prophylaxis requires primary prevention in those at high risk of fracture. Bisphosphonates are the treatment of choice, and calcium and vitamin D supplements are also indicated in the majority of individuals. Organized care programs together with the use of evidence-based guidelines have the potential to improve significantly the management of this serious complication of glucocorticoid therapy.
糖皮质激素诱导的骨质疏松症是一个常见但仍相对被忽视的问题，基层和二级医疗保健医生对此的认识水平较低。骨折在开始治疗后不久就会出现，有效的预防需要对骨折高危人群进行一级预防。双膦酸盐是首选治疗药物，大多数患者也需要补充钙和维生素D。有组织的护理计划以及使用循证指南有可能显著改善糖皮质激素治疗这一严重并发症的管理。
