Akhras F, Jackson G
Academic Unit of Cardiovascular Medicine, Westminster Hospital, London, U.K.
Int J Cardiol. 1991 Nov;33(2):259-66. doi: 10.1016/0167-5273(91)90356-t.
Eighteen hypertensive patients with a resting diastolic blood pressure between 100 and 120 mmHg who also had angina and proven coronary arterial disease entered a dose titration study to evaluate the efficacy of captopril as a single therapy in hypertension and coexisting stable angina. Captopril was administered for 2 weeks at 25 or 50 mg three times daily and the patients evaluated subjectively and by maximal symptom limited treadmill exercise testing. In comparison to placebo captopril 25 mg and 50 mg dosage increased time to 1 mm ST depression from 188.2 +/- 24.4 sec on placebo to 337.6 +/- 29.5 and 364.2 +/- 36.2 sec respectively (P less than 0.01). The maximum ST segment depression was reduced from 2.5 +/- 0.25 mm on placebo to 1.4 +/- 0.22 mm on captopril 25 mg and 1.2 +/- 0.30 mm on captopril 50 mg (P less than 0.01). Exercise duration increased from 310.3 +/- 21.4 sec on placebo to 438.3 +/- 27.3 sec on captopril 25 mg and to 460.9 +/- 26.5 sec on captopril 50 mg (P less than 0.01). The resting systolic blood pressure decreased from 184.1 +/- 4.7 mmHg on placebo to 159 +/- 4.2 mmHg on captopril 25 mg and to 150.9 +/- 4.6 mmHg on captopril 50 mg (less than 0.01). Similarly, diastolic blood pressure decreased from 111.6 +/- 2.1 mmHg on placebo to 93.8 +/- 1.3 mmHg on captopril 25 mg and to 90.0 +/- 1.7 mmHg on captopril 50 mg (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
18名静息舒张压在100至120 mmHg之间且患有心绞痛及确诊冠状动脉疾病的高血压患者进入一项剂量滴定研究，以评估卡托普利作为单一疗法治疗高血压及并存的稳定型心绞痛的疗效。卡托普利以每日三次、每次25或50 mg的剂量给药2周，通过主观评估及最大症状受限平板运动试验对患者进行评估。与安慰剂相比，卡托普利25 mg和50 mg剂量组使出现1 mm ST段压低的时间从安慰剂组的188.2±24.4秒分别增加至337.6±29.5秒和364.2±36.2秒（P<0.01）。最大ST段压低从安慰剂组的2.5±0.25 mm降至卡托普利25 mg组的1.4±0.22 mm及卡托普利50 mg组的1.2±0.30 mm（P<0.01）。运动持续时间从安慰剂组的310.3±21.4秒增加至卡托普利25 mg组的438.3±27.3秒及卡托普利50 mg组的460.9±26.5秒（P<0.01）。静息收缩压从安慰剂组的184.1±4.7 mmHg降至卡托普利25 mg组的159±4.2 mmHg及卡托普利50 mg组的150.9±4.6 mmHg（<0.01）。同样，舒张压从安慰剂组的111.6±2.1 mmHg降至卡托普利25 mg组的93.8±1.3 mmHg及卡托普利50 mg组的90.0±1.7 mmHg（P<0.01）。（摘要截选至250字）
