结核分枝杆菌中embB基因306密码子突变与耐药性的关联
Association between embB codon 306 mutations and drug resistance in Mycobacterium tuberculosis.
作者信息
Shen Xin, Shen Guo-miao, Wu Jie, Gui Xiao-hong, Li Xia, Mei Jian, DeRiemer Kathryn, Gao Qian
机构信息
Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, Shanghai 20032, China.
出版信息
Antimicrob Agents Chemother. 2007 Jul;51(7):2618-20. doi: 10.1128/AAC.01516-06. Epub 2007 Apr 16.
Abstract
embB306 mutants were detected in both ethambutol (EMB)-resistant and EMB-susceptible strains of Mycobacterium tuberculosis. Multidrug-resistant (MDR) strains had a higher proportion of embB306 mutants than non-MDR strains (odds ratio, 6.78; P < 0.001). The embB306 locus is a candidate marker for rapid detection of MDR and extremely drug resistant tuberculosis.
摘要
在结核分枝杆菌的耐乙胺丁醇（EMB）菌株和对EMB敏感的菌株中均检测到embB306突变体。耐多药（MDR）菌株中embB306突变体的比例高于非MDR菌株（优势比，6.78；P<0.001）。embB306基因座是快速检测耐多药和广泛耐药结核病的候选标志物。
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