Anderson K O, Giralt S A, Mendoza T R, Brown J O, Neumann J L, Mobley G M, Wang X S, Cleeland C S
Department of Symptom Research, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
Bone Marrow Transplant. 2007 Jun;39(12):759-66. doi: 10.1038/sj.bmt.1705664. Epub 2007 Apr 16.
Patients who undergo autologous peripheral blood stem cell (PBSC) transplantation experience multiple symptoms that adversely affect quality of life. We assessed symptoms during the acute phase of autologous PBSC transplantation to determine the severity of individual symptoms and to determine overall symptom profiles in 100 patients with multiple myeloma or non-Hodgkin's lymphoma. Study subjects completed the blood and marrow transplantation module of the M. D. Anderson Symptom Inventory before hospitalization, during conditioning, on day of transplantation, at nadir (the time of lowest white blood cell count) and on day 30 post-transplantation. Additional symptom, quality-of-life and medical status measures were collected. Symptom means were mild at baseline, intensified during conditioning, peaked at nadir and decreased by day 30. At nadir, the most severe symptoms for the entire patient sample were lack of appetite, fatigue, weakness, feeling sick, disturbed sleep, nausea and diarrhea. Cancer diagnosis was a significant predictor of changes in symptoms over time. The patterns of fatigue, pain, sleep disturbance and lack of appetite were significantly different for patients with multiple myeloma as compared with patients with non-Hodgkin's lymphoma.
接受自体外周血干细胞（PBSC）移植的患者会经历多种对生活质量产生不利影响的症状。我们评估了100例多发性骨髓瘤或非霍奇金淋巴瘤患者在自体PBSC移植急性期的症状，以确定个体症状的严重程度并确定总体症状概况。研究对象在住院前、预处理期间、移植当天、最低点（白细胞计数最低时）以及移植后第30天完成了MD安德森症状量表的血液和骨髓移植模块。还收集了其他症状、生活质量和医疗状况指标。症状均值在基线时较轻，在预处理期间加剧，在最低点达到峰值，并在第30天下降。在最低点时，整个患者样本中最严重的症状是食欲不振、疲劳、虚弱、恶心、睡眠障碍、恶心和腹泻。癌症诊断是症状随时间变化的一个重要预测因素。与非霍奇金淋巴瘤患者相比，多发性骨髓瘤患者的疲劳、疼痛、睡眠障碍和食欲不振模式有显著差异。
