Stanciu C, Trifan Anca, Cojocariu Camelia
Institute of Gastroenterology and Hepatology, Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2006 Oct-Dec;110(4):765-70.
Liver fibrosis is the main determinant of clinical outcomes of chronic hepatitis C. Liver biopsy is still considered the gold-standard for assessing liver fibrosis. However, liver biopsy is an invasive procedure associated with morbidity and mortality and has several limitations. Moreover, liver biopsy is not well accepted by the patients, especially when repeated examinations are needed, and its accuracy in assessing fibrosis is questionable due to sampling errors, intraobserver and interobserver discrepancies. Therefore, over the last years there has been an increasing interest and desire for non-invasive tests to assess the stage of liver fibrosis in patients with chronic hepatitis C. There are three main groups of non-invasive methodologies for the assessment of liver fibrosis: serum markers, imaging techniques, and transient elastrography. This review summarizes current information on transient elastography used for non-invasive diagnosis of liver fibrosis in patients with chronic hepatitis C.
肝纤维化是慢性丙型肝炎临床预后的主要决定因素。肝活检仍被视为评估肝纤维化的金标准。然而，肝活检是一种有创检查，存在发病和死亡风险，且有诸多局限性。此外，患者对肝活检接受度不高，尤其是需要重复检查时，而且由于抽样误差、观察者内和观察者间差异，其评估纤维化的准确性也存在疑问。因此，在过去几年中，人们对用于评估慢性丙型肝炎患者肝纤维化分期的非侵入性检查越来越感兴趣并寄予厚望。评估肝纤维化的非侵入性方法主要有三大类：血清标志物、成像技术和瞬时弹性成像。本综述总结了目前关于瞬时弹性成像用于慢性丙型肝炎患者肝纤维化非侵入性诊断的信息。
