Briegel W, Schneider M, Schwab K O
Department of Child and Adolescent Psychiatry, Leopoldina Hospital, Gustav-Adolf-Strasse 4, 97422 Schweinfurt, Germany.
Child Care Health Dev. 2007 May;33(3):319-24. doi: 10.1111/j.1365-2214.2006.00654.x.
22q11.2 deletion syndrome (22q11.2 DS) can be associated with a variety of somatic symptoms, developmental delays and psychiatric disorders. At present, there is little information on early behaviour problems, and nothing is known about parental stress and possible relations between these factors. Therefore, the aim of this study was to investigate behaviour problems of infants with 22q11.2 DS, and their primary caregivers' stress.
Parents of infants with 22q11.2 DS known to the German 22q11.2 deletion syndrome foundation were anonymously asked to fill out several questionnaires, e.g. the Child Behavior Checklist (CBCL) 1.5-5.
The primary caregivers of 22/30 children [12 boys and 10 girls aged 1 year 8 months to 3 years 11 months (mean age: 2 years 9 months)] sent back filled-out questionnaires. Seventeen out of 21 children showed motor, and 15/21 language delay. Five out of 21 children were rated as clinical on at least one CBCL 1.5-5 scale. The patients' age was correlated with anxiety problems, and girls had significantly more sleep problems than boys. Compared with the general population, the primary caregivers did not experience higher levels of strain, and compared with parents of mentally and/or physically handicapped children, their parental stress was significantly lower. Parental stress and strain were correlated to a variety of child behaviour problems, e.g. externalizing and anxious/depressed behaviour.
Longitudinal studies are required to show whether behaviour problems and parental stress worsen when 22q11.2 DS patients grow older.
22q11.2缺失综合征（22q11.2 DS）可能与多种躯体症状、发育迟缓及精神障碍相关。目前，关于早期行为问题的信息较少，对于父母压力以及这些因素之间的可能关系也一无所知。因此，本研究的目的是调查22q11.2 DS婴儿的行为问题及其主要照顾者的压力。
德国22q11.2缺失综合征基金会已知的22q11.2 DS婴儿的父母被匿名要求填写几份问卷，例如儿童行为量表（CBCL）1.5 - 5岁版。
30名儿童中的22名[12名男孩和10名女孩，年龄在1岁8个月至3岁11个月之间（平均年龄：2岁9个月）]的主要照顾者寄回了填写好的问卷。21名儿童中有17名存在运动发育迟缓，15/21存在语言发育迟缓。21名儿童中有5名在至少一项CBCL 1.5 - 5量表上被评定为临床问题。患儿年龄与焦虑问题相关，女孩的睡眠问题显著多于男孩。与一般人群相比，主要照顾者并未经历更高水平的压力，与精神和/或身体残疾儿童的父母相比，他们的父母压力显著更低。父母压力与多种儿童行为问题相关，例如外化行为和焦虑/抑郁行为。
需要进行纵向研究以表明22q11.2 DS患者长大后行为问题和父母压力是否会恶化。
