凝血因子XI缺乏症的妊娠结局：33例凝血因子XI缺乏症女性的流产、产前和产后出血发生率

Pregnancy outcome in Factor XI deficiency: incidence of miscarriage, antenatal and postnatal haemorrhage in 33 women with Factor XI deficiency.

作者信息

Myers B, Pavord S, Kean L, Hill M, Dolan G

机构信息

Haematology Department, Queen's Medical Centre, Nottingham, UK.

出版信息

BJOG. 2007 May;114(5):643-6. doi: 10.1111/j.1471-0528.2007.01296.x.

DOI:10.1111/j.1471-0528.2007.01296.x

PMID:17439571

Abstract

Pregnancy complications in women with Factor XI deficiency were assessed in this retrospective analysis. All nonnulliparous women registered with Factor XI deficiency in the East Midlands region were included. Each woman was classified into 'bleeder' or 'nonbleeder'. Rates of antenatal and postnatal bleeding and miscarriage rate were recorded. A total of 33 women had 105 pregnancies. Pregnancy and delivery was uneventful in 70% of the cases. Postpartum haemorrhage (PPH) appears increased in women with a 'bleeding' phenotype with a highly significant difference between 'bleeders' and 'nonbleeders' (relative risk [RR] 7.2; CI 1.99-25.9). Miscarriage rate appeared unchanged. We conclude that PPH is increased in a subgroup with a bleeding phenotype. Larger studies are needed to define the underlying factors.

摘要

在这项回顾性分析中，对患有因子XI缺乏症的女性的妊娠并发症进行了评估。纳入了东米德兰兹地区所有登记患有因子XI缺乏症的未生育女性。每位女性被分为“出血者”或“非出血者”。记录产前和产后出血率以及流产率。共有33名女性怀孕105次。70%的病例妊娠和分娩过程顺利。产后出血（PPH）在具有“出血”表型的女性中似乎有所增加，“出血者”和“非出血者”之间存在高度显著差异（相对风险[RR]7.2；CI 1.99 - 25.9）。流产率似乎没有变化。我们得出结论，具有出血表型的亚组中产后出血增加。需要进行更大规模的研究来确定潜在因素。