Adelson Miriam, Peles Einat, Bodner Gershon, Kreek Mary Jeanne
Tel-Aviv Elias Sourasky Medical Center, 6, Weizman St, Tel-Aviv, Israel.
J Addict Dis. 2007;26(1):15-26. doi: 10.1300/J069v26n01_03.
To evaluate the relation between high methadone doses and methadone serum levels in MMT patients.
One hundred fifty-one steady methadone-dose patients were evaluated for methadone serum levels using GCMS. Urine samples during the month prior to the study-day were analysed and defined as positive if any sample was positive for any drug.
Methadone dose correlated with methadone serum levels (Pearson R = 0.36, P < 0.0005). In 53 patients with no drug abuse, correlation was stronger (R = 0.53, P < 0.0005) than in 98 patients with any drug abuse (R = 0.25, P = 0.01).
We extended the well-established correlation between methadone doses and serum levels in patients receiving low or moderate (60 to 120 mg/day) to high methadone doses (up to 290 mg/day).
评估美沙酮维持治疗（MMT）患者中高剂量美沙酮与美沙酮血清水平之间的关系。
对151名美沙酮剂量稳定的患者使用气相色谱 - 质谱联用（GCMS）法评估美沙酮血清水平。分析研究当天前一个月的尿液样本，若任何一份样本对任何药物呈阳性，则定义为阳性。
美沙酮剂量与美沙酮血清水平相关（Pearson相关系数R = 0.36，P < 0.0005）。在53名无药物滥用的患者中，相关性更强（R = 0.53，P < 0.0005），高于98名有任何药物滥用的患者（R = 0.25，P = 0.01）。
我们将接受低或中等剂量（60至120毫克/天）美沙酮治疗患者中美沙酮剂量与血清水平之间已确立的相关性扩展至高剂量美沙酮（高达290毫克/天）。
