Patkó T, Simó M, Arányi Z
Department of Otorhinolaryngology, St John's Hospital, 1125 Budapest, Diósárok 1-3, Hungary.
Mult Scler. 2007 Mar;13(2):193-8. doi: 10.1177/1352458506070940. Epub 2007 Jan 29.
Vestibular evoked myogenic potential (VEMP) assesses the sacculo-spinal pathway. The aim of our study was to examine sensitivity and factors determining abnormality of VEMP, indicative of brainstem dysfunction, in patients with multiple sclerosis (MS). Thirty healthy subjects and 30 MS patients were examined. All healthy subjects showed a normal biphasic response. Twelve of the 30 MS patients (40%) had abnormal recordings. There was a significant difference between MS patients and control subjects with respect to P13 latency (longer in the MS group) and P13-N23 amplitude (lower in the MS group). VEMP abnormalities were statistically significantly related to the presence of brainstem demyelinative lesions and a weaker correlation was found with disease duration. Clinical signs of vestibular dysfunction at any point during the course of the disease did not seem to affect the chances of obtaining abnormal VEMPs. Although the sensitivity of VEMP in detecting abnormality in MS patients is relatively low, its significance is evident in that it is the only electrophysiological method that is able to detect dysfunction in central vestibular pathways.
前庭诱发肌源性电位（VEMP）评估球囊脊髓通路。我们研究的目的是检测多发性硬化症（MS）患者中VEMP的敏感性以及决定其异常的因素，这些异常表明脑干功能障碍。对30名健康受试者和30名MS患者进行了检查。所有健康受试者均表现出正常的双相反应。30名MS患者中有12名（40%）记录异常。MS患者与对照受试者在P13潜伏期（MS组较长）和P13-N23波幅（MS组较低）方面存在显著差异。VEMP异常与脑干脱髓鞘病变的存在在统计学上显著相关，且与病程的相关性较弱。在疾病过程中任何时间点的前庭功能障碍临床体征似乎都不影响获得异常VEMP的几率。尽管VEMP在检测MS患者异常方面的敏感性相对较低，但其意义在于它是唯一能够检测中枢前庭通路功能障碍的电生理方法。
