Vetrugno Michele, Trabucco Tiziana, Sisto Dario, Troysi Valeria, Sborgia Giancarlo
Department of Ophthalmology and Otolaryngology, University of Bari, Bari, Italy.
Ophthalmologica. 2007;221(3):190-4. doi: 10.1159/000099300.
To evaluate the influence of different degrees of myopia on retinal nerve fiber layer (RNFL) as measured by scanning laser polarimetry (SLP) with variable corneal compensator (VCC) in healthy eyes.
One hundred and seventy-four healthy age-matched subjects with low to high myopic and emmetropic eyes underwent RNFL measurement by means of GDxVCC. The GDx parameters included in the analysis were: Temporal-superior-nasal-inferior thickness (TSNIT) average, Superior average, Inferior average, TSNIT standard deviation, Inter-eye symmetry, NFI, Symmetry, Superior ratio, Inferior ratio, Superior/nasal, Maximum modulation, Superior maximum, Inferior maximum, Ellipse modulation, Normalized superior area, Normalized inferior area, Ellipse standard deviation, Ellipse average. The mean value of each SLP parameter of myopic eyes was compared with the mean value of the same parameter of emmetropic eyes.
Mean myopia was 3.9 +/- 1.5 dpt (range: -2 to -8.25 dpt). TNSIT average was higher in myopic group (p = 0.0111), together with Superior average (p = 0.0244), Symmetry (p < 0.0001) and Ellipse average (p = 0.0111). Two ratio parameters, Superior ratio and Inferior ratio, were higher in emmetropic eyes (p = 0.0179 in both cases). In both the myopic and the emmetropic group, all the SLP assessments of the RNFL fell within the normal range, according to the GDx database.
Low to high myopia is not related to clinically relevant variations of SLP parameters, as assessed with GDx-VCC.
评估在健康眼中，使用可变角膜补偿器（VCC）的扫描激光偏振仪（SLP）测量不同程度近视对视网膜神经纤维层（RNFL）的影响。
174名年龄匹配的健康受试者，包括低度至高度近视和正视眼，通过GDxVCC进行RNFL测量。分析中纳入的GDx参数包括：颞上鼻下厚度（TSNIT）平均值、上方平均值、下方平均值、TSNIT标准差、眼间对称性、神经纤维指数（NFI）、对称性、上方比值、下方比值、上方/鼻侧、最大调制、上方最大值、下方最大值、椭圆调制、标准化上方面积、标准化下方面积、椭圆标准差、椭圆平均值。将近视眼各SLP参数的平均值与正视眼相同参数的平均值进行比较。
平均近视度数为3.9±1.5屈光度（范围：-2至-8.25屈光度）。近视眼组的TSNIT平均值较高（p = 0.0111），上方平均值（p = 0.0244）、对称性（p < 0.0001）和椭圆平均值（p = 0.0111）也较高。两个比值参数，即上方比值和下方比值，正视眼中较高（两种情况均为p = 0.0179）。根据GDx数据库，在近视眼组和正视眼组中，RNFL的所有SLP评估均在正常范围内。
使用GDx-VCC评估时，低度至高度近视与SLP参数的临床相关变化无关。
