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探寻宝藏：T-bet的故事

Trawling for treasure: tales of T-bet.

作者信息

Glimcher Laurie H

机构信息

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

出版信息

Nat Immunol. 2007 May;8(5):448-50. doi: 10.1038/ni0507-448.

DOI:10.1038/ni0507-448
PMID:17440449
Abstract

Discovering the transcription factors that direct lineage commitment in the T helper cell was a formidable task. Laurie Glimcher describes how she and Susanne Szabo hunted down T-bet, a transcription factor that is a 'master regulator' of commitment to the T helper type 1 lineage.

摘要

发现指导T辅助细胞谱系定向分化的转录因子是一项艰巨的任务。劳里·格林切尔描述了她和苏珊娜·萨博是如何找到T-bet的，T-bet是一种转录因子，是T辅助1型细胞谱系定向分化的“主调控因子”。

相似文献

1
Trawling for treasure: tales of T-bet.探寻宝藏：T-bet的故事
Nat Immunol. 2007 May;8(5):448-50. doi: 10.1038/ni0507-448.
2
Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12.1型辅助性T淋巴细胞由γ干扰素和白细胞介素-12介导的顺序极化和印记
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Onecut transcription factor OC2 is a direct target of T-bet in type-1 T-helper cells.单剪接转录因子OC2是1型辅助性T细胞中T-bet的直接靶标。
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T-bet expression is regulated by EGR1-mediated signaling in activated T cells.T-bet的表达在活化的T细胞中受EGR1介导的信号传导调控。
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The calculus of integrating differentiation: timing control of T-bet.整合分化的演算：T-bet的时间控制
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Instruction of naive CD4+ T-cell fate to T-bet expression and T helper 1 development: roles of T-cell receptor-mediated signals.初始CD4+ T细胞向T-bet表达及辅助性T细胞1发育的命运指令：T细胞受体介导信号的作用
Immunology. 2007 Oct;122(2):210-21. doi: 10.1111/j.1365-2567.2007.02630.x. Epub 2007 May 9.
7
Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa.转化生长因子β的阻断上调T盒转录因子T-bet，并增加人肠道黏膜中1型辅助性T细胞细胞因子和基质金属蛋白酶-3的产生。
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CD8(+) T cell differentiation: choosing a path through T-bet.CD8（+）T细胞分化：通过T-bet选择一条途径。
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Overexpression of T-bet in T cells accelerates autoimmune glomerulonephritis in mice with a dominant Th1 background.T细胞中T-bet的过表达会加速具有显性Th1背景的小鼠的自身免疫性肾小球肾炎。
J Nephrol. 2009 Jan-Feb;22(1):123-9.

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Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.转录因子T-bet的DNA结合结构域的晶体结构表明可同时识别远距离基因组位点。
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