Hattori Yasunao, Kimura Yuka, Moroda Aki, Konno Hiroyuki, Abe Masato, Miyoshi Hideto, Goto Tetsuhisa, Makabe Hidefumi
Interdisciplinary Graduate School of Science and Technology, Shinshu University, 8304 Minami-Minowa, Kamiina, Nagano 399-4598, Japan.
Chem Asian J. 2006 Dec 18;1(6):894-904. doi: 10.1002/asia.200600261.
The asymmetric total synthesis of murisolin, (15R, 16R, 19R, 20S)-murisolin A, and (15R, 16R, 19S, 20S)-16,19-cis-murisolin was performed by using an epoxy alcohol as a versatile chiral building block for synthesizing the stereoisomers of mono-THF annonaceous acetogenins. The inhibitory activity of these murisolin compounds was examined with bovine heart mitochondrial complex I, and they showed almost the same activity.
通过使用环氧醇作为通用手性砌块来合成单四氢呋喃番荔枝内酯的立体异构体，实现了鼠李素、(15R, 16R, 19R, 20S)-鼠李素A和(15R, 16R, 19S, 20S)-16,19-顺式鼠李素的不对称全合成。用牛心线粒体复合物I检测了这些鼠李素化合物的抑制活性，它们表现出几乎相同的活性。
