Freeman S, Sohmer H
Department of Physiology, Hebrew University-Hadassah Medical School, POB 12272, Jerusalem, Israel.
Electroencephalogr Clin Neurophysiol. 1996 Jul;100(4):362-9. doi: 10.1016/0168-5597(96)95690-7.
Somatosensory evoked potentials were elicited in anesthetized rats by electrical stimulation of the forepaw (F-SEP) or the vibrissae (V-SEP) and were compared in order to study which of these is a more valid animal model for studying the physiology and pathophysiology of somatosensory evoked potentials (SEPs) that are often recorded in man in a clinical setting. Intensity and rate functions were measured for the two potentials. The V-SEPs had larger amplitudes than the F-SEPs at high stimulus intensity and low stimulus rate. Furthermore, the ratios of the maximal amplitude of the F-SEP to that of the V-SEP (0.66) and of the areas under the curves of the two responses (0.75) reflected the smaller representation of the forepaw in the primary somatosensory cortex of the rat, compared to the vibrissae (ratio of cortical areas about 0.79). The differences should be taken into account when using median nerve SEP in the rat as a model of the human SEP. Study of V-SEPs in rat may provide insight into trigeminal nerve SEPs in man, which are also occasionally used for neurological evaluation.
在麻醉大鼠中，通过电刺激前爪（F-SEP）或触须（V-SEP）引出体感诱发电位，并进行比较，以研究哪一种是更有效的动物模型，用于研究在临床环境中经常在人类身上记录的体感诱发电位（SEPs）的生理学和病理生理学。测量了两种电位的强度和频率函数。在高刺激强度和低刺激频率下，V-SEP的波幅大于F-SEP。此外，F-SEP与V-SEP的最大波幅之比（0.66）以及两种反应曲线下面积之比（0.75）反映出，与触须相比，大鼠初级体感皮层中前爪的代表区较小（皮层面积比约为0.79）。在将大鼠正中神经SEP用作人类SEP模型时，应考虑到这些差异。对大鼠V-SEP的研究可能有助于深入了解人类的三叉神经SEP，后者也偶尔用于神经学评估。
