一种雄激素衍生物对大鼠化学诱导的预先形成的乳腺肿瘤的影响。
Effects of an androgenic derivative on pre-established mammary tumours chemically induced in the rat.
作者信息
Escrich E, Ribalta T, Muntané J, Ruiz de Villa M C, Murillo J, Saez S
机构信息
Departament de Biologia Cellular i Fisiologia, Facultat de Medicina, Universitat Autónoma de Barcelona, Spain.
出版信息
J Cancer Res Clin Oncol. 1991;117(6):575-82. doi: 10.1007/BF01613291.
The effects were studied of an androgenic derivative--danazol--administered at doses of 10-12 mg kg-1 day-1 during 97 days to rats with dimethylbenz[a] anthracene-induced mammary tumours. Our main observations were as follows. (a) Danazol did not influence ovarian function at the end of the assay. (b) The treatment with danazol reduced the incidence (P less than 0.05), number of tumours (P less than 0.05) and volume of malignant mammary tumours; on the other hand, the values of these parameters for benign tumours and those of doubtful expression were similar in both experimental groups. (c) Such differential action of Danazol seems to be due to the different incidence and/or content of receptors of both types of tumours. (d) The latter results lead to a hypothesis for the mechanism of action of danazol based on its behaviour at different levels.
研究了雄激素衍生物达那唑对二甲基苯并[a]蒽诱导的大鼠乳腺肿瘤的影响。以10 - 12毫克/千克·天的剂量给大鼠连续97天服用达那唑。我们的主要观察结果如下：(a) 在实验结束时，达那唑对卵巢功能没有影响。(b) 达那唑治疗降低了恶性乳腺肿瘤的发生率（P < 0.05）、肿瘤数量（P < 0.05）和体积；另一方面，两个实验组中良性肿瘤以及表达情况可疑的肿瘤的这些参数值相似。(c) 达那唑的这种差异作用似乎是由于两种肿瘤受体的发生率和/或含量不同。(d) 后一结果基于达那唑在不同水平的表现，提出了其作用机制的假说。
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