Dmowski W P, Headley S, Radwanska E
Fertil Steril. 1983 Jan;39(1):49-55. doi: 10.1016/s0015-0282(16)46757-9.
The effect of danazol on pulsatile luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estradiol (E2) secretion was examined in eight premenopausal women by serial blood sampling on day 10 of the control and first treatment cycles and during 2 subsequent months of treatment. The mean frequency of LH pulses decreased, while the mean pulse amplitude and increment increased (P less than 0.05). The mean LH concentrations were significantly suppressed in four of eight subjects. The mean frequency of E2 pulses, mean increment, and mean integrated area were decreased (P less than 0.05). The mean integrated FSH area did not change significantly during treatment, and we were not able to demonstrate unequivocal FSH pulses. We conclude that danazol in premenopausal women (1) lowers serum E2 concentrations by decreasing the frequency and increment of E2 pulses, (2) prevents compensatory gonadotropin rise, and (3) lowers the frequency but increases the amplitude and increment of LH pulses. The latter change reflects probably divergent effects of the drug on the pituitary and hypothalamus and results in an inconsistent lowering of basal LH levels.
通过在对照周期和第一个治疗周期的第10天以及随后2个月的治疗期间对8名绝经前妇女进行连续采血，研究了达那唑对促黄体生成素（LH）、促卵泡激素（FSH）和雌二醇（E2）脉冲式分泌的影响。LH脉冲的平均频率降低，而平均脉冲幅度和增量增加（P<0.05）。8名受试者中有4名的平均LH浓度受到显著抑制。E2脉冲的平均频率、平均增量和平均积分面积均降低（P<0.05）。治疗期间平均FSH积分面积无显著变化，且我们未能明确证实FSH脉冲。我们得出结论，绝经前妇女使用达那唑（1）通过降低E2脉冲的频率和增量来降低血清E2浓度，（2）防止促性腺激素的代偿性升高，（3）降低LH脉冲的频率，但增加其幅度和增量。后一种变化可能反映了该药物对垂体和下丘脑的不同作用，并导致基础LH水平的降低不一致。
