Laboratory of Molecular Infectology, Department of Biochemistry, School of Medicine, Hospital Universitario 'Dr Jose E. Gonzalez', UANL, Monterrey NL, México.
Hepatol Res. 2007 May;37(5):311-6. doi: 10.1111/j.1872-034X.2007.00035.x.
The prevalence of hepatitis C virus (HCV) infection, risk factors and HCV genotypes in 140 HIV-1 infected individuals from northern Mexico was determined.
Hepatitis C infection was confirmed by the detection of anti-HCV antibodies and HCV-RNA in sera, and genotyping was performed by the InnoLiPA-HCV genotype assay.
Seventeen (12.1%) out of 140 HIV-infected individuals were found to be HCV-positive. Coinfected individuals were more likely to be male (87%). The most frequent genotype was 1a (41%), followed by 1b (29.4%), 2a/c (17.6%), 2b (5.9%) and 3 (5.9%). Serum transaminase concentrations (AST and ALT) were higher in coinfected patients. Among the risk factors for coinfection: sexual transmission was the most frequently observed (men who have sex with men (MSM); 64.7% and bisexual behavior; 64.7%) followed by intravenous drug users (IVDU) (53%). There was no association of the HCV genotypes with the age and risk factors for HIV-1 and HCV infection observed in the studied patients.
The results suggest that the prevalence of HIV-1/HCV coinfection in Mexico is lower than in other American countries.
本研究旨在确定来自墨西哥北部的 140 名 HIV-1 感染者中丙型肝炎病毒 (HCV) 感染的流行率、危险因素和 HCV 基因型。
通过检测血清中的抗 HCV 抗体和 HCV-RNA 来确认 HCV 感染，并通过 InnoLiPA-HCV 基因型检测试剂盒进行基因分型。
在 140 名 HIV 感染个体中，发现 17 人（12.1%）为 HCV 阳性。合并感染的个体更可能为男性（87%）。最常见的基因型为 1a（41%），其次为 1b（29.4%）、2a/c（17.6%）、2b（5.9%）和 3（5.9%）。合并感染者的血清转氨酶浓度（AST 和 ALT）更高。在合并感染的危险因素中：性传播是最常见的（男男性接触者（MSM）占 64.7%，双性恋行为占 64.7%），其次是静脉吸毒者（IVDU）（53%）。在研究对象中，HCV 基因型与 HIV-1 和 HCV 感染的年龄和危险因素之间没有关联。
研究结果表明，墨西哥 HIV-1/HCV 合并感染的流行率低于其他美洲国家。
