墨西哥北部 HIV-1 感染者中的丙型肝炎病毒感染。

Hepatitis C virus infection among HIV-1 infected individuals from northern Mexico.

机构信息

Laboratory of Molecular Infectology, Department of Biochemistry, School of Medicine, Hospital Universitario 'Dr Jose E. Gonzalez', UANL, Monterrey NL, México.

出版信息

Hepatol Res. 2007 May;37(5):311-6. doi: 10.1111/j.1872-034X.2007.00035.x.

DOI:10.1111/j.1872-034X.2007.00035.x

PMID:17441802

Abstract

AIMS

The prevalence of hepatitis C virus (HCV) infection, risk factors and HCV genotypes in 140 HIV-1 infected individuals from northern Mexico was determined.

METHODS

Hepatitis C infection was confirmed by the detection of anti-HCV antibodies and HCV-RNA in sera, and genotyping was performed by the InnoLiPA-HCV genotype assay.

RESULTS

Seventeen (12.1%) out of 140 HIV-infected individuals were found to be HCV-positive. Coinfected individuals were more likely to be male (87%). The most frequent genotype was 1a (41%), followed by 1b (29.4%), 2a/c (17.6%), 2b (5.9%) and 3 (5.9%). Serum transaminase concentrations (AST and ALT) were higher in coinfected patients. Among the risk factors for coinfection: sexual transmission was the most frequently observed (men who have sex with men (MSM); 64.7% and bisexual behavior; 64.7%) followed by intravenous drug users (IVDU) (53%). There was no association of the HCV genotypes with the age and risk factors for HIV-1 and HCV infection observed in the studied patients.

CONCLUSION

The results suggest that the prevalence of HIV-1/HCV coinfection in Mexico is lower than in other American countries.

摘要

目的

本研究旨在确定来自墨西哥北部的 140 名 HIV-1 感染者中丙型肝炎病毒 (HCV) 感染的流行率、危险因素和 HCV 基因型。

方法

通过检测血清中的抗 HCV 抗体和 HCV-RNA 来确认 HCV 感染，并通过 InnoLiPA-HCV 基因型检测试剂盒进行基因分型。

结果

在 140 名 HIV 感染个体中，发现 17 人（12.1%）为 HCV 阳性。合并感染的个体更可能为男性（87%）。最常见的基因型为 1a（41%），其次为 1b（29.4%）、2a/c（17.6%）、2b（5.9%）和 3（5.9%）。合并感染者的血清转氨酶浓度（AST 和 ALT）更高。在合并感染的危险因素中：性传播是最常见的（男男性接触者（MSM）占 64.7%，双性恋行为占 64.7%），其次是静脉吸毒者（IVDU）（53%）。在研究对象中，HCV 基因型与 HIV-1 和 HCV 感染的年龄和危险因素之间没有关联。