墨西哥东北部感染患者的丙型肝炎病毒（HCV）基因分型

Genotyping of hepatitis C virus (HCV) in infected patients from Northeast Mexico.

作者信息

Rivas-Estilla Ana María, Cordero-Pérez Paula, Trujillo-Murillo Karina del Carmen, Ramos-Jiménez Javier, Chen-López Carlos, Garza-Rodríguez María de L, Ramírez-Gutiérrez Angel, Muñoz-Espinosa Linda

机构信息

Department of Biochemistry, School of Medicine and University Hospital Dr. José E. González, UANL, Monterrey, NL, Mexico.

出版信息

Ann Hepatol. 2008 Apr-Jun;7(2):144-7.

PMID:18626432

Abstract

UNLABELLED

Information about HCV genotypes in infected patients from different regions of Mexico is limited.

OBJECTIVE

To determine the prevalence of HCV genotypes in a group of HCV infected patients who attended a third level Hospital in Northeast of Mexico.

METHODS

Genotyping analysis was performed using the InnoLiPA-HCV genotype assay in 147 patients (65 males and 82 females, mean age 44 +/- 12 years) with positive anti-HCV antibodies and detectable HCV-RNA levels.

RESULTS

Infected individuals were more likely to be female (56%). Histological data showed that 63% of the patients had chronic hepatitis, while the remainder presented cirrhosis (37%). The most frequent HCV genotype was 1 (73%). We found the following distribution: genotype 1 (2.7%), 1a (28.6%), 1b (37.4%), 1a/1b (4.1%), 2a (1.4%), 2b (8.8%), 2c (0.7%), 2a/2c (2.7%), 3 (2%), 3a (10.2%), 4 (0.7%) and 4c (0.7%). The most frequent associated risk factor was blood transfusion (72.5%).

CONCLUSION

Prevalence of HCV genotypes in the Northeast of Mexico is similar to those reported previously in other Mexican regions and the most frequent risk factor continues being blood transfusion.

摘要

未标注

关于墨西哥不同地区感染患者丙型肝炎病毒（HCV）基因型的信息有限。

目的

确定在墨西哥东北部一家三级医院就诊的一组HCV感染患者中HCV基因型的流行情况。

方法

对147例抗HCV抗体阳性且HCV-RNA水平可检测的患者（65例男性和82例女性，平均年龄44±12岁）使用InnoLiPA-HCV基因型检测法进行基因分型分析。

结果

感染个体中女性更常见（56%）。组织学数据显示，63%的患者患有慢性肝炎，其余患者为肝硬化（37%）。最常见的HCV基因型是1型（73%）。我们发现以下分布情况：基因型1（2.7%）、1a（28.6%）、1b（37.4%）、1a/1b（4.1%）、2a（1.4%）、2b（8.8%）、2c（0.7%）、2a/2c（2.7%）、3型（2%）、3a（10.2%）、4型（0.7%）和4c（0.7%）。最常见的相关危险因素是输血（72.5%）。