Theodore William H, Hasler Gregor, Giovacchini Giampiero, Kelley Kathleen, Reeves-Tyer Pat, Herscovitch Peter, Drevets Wayne
Clinical Epilepsy Section, National Institute of Neurological Diseases and Stroke/NIH, Bethesda, MD 20892, USA.
Epilepsia. 2007 Aug;48(8):1526-30. doi: 10.1111/j.1528-1167.2007.01089.x. Epub 2007 Apr 18.
To study the relation of hippocampal 5HT1A receptor binding to symptoms of depression in patients with temporal lobe epilepsy. Depression is common in people with epilepsy, and reduced 5HT1A binding has been reported in patients with primary depressive disorders.
We studied 45 patients with temporal lobe epilepsy confirmed by ictal video-EEG recording. Mood was assessed with the Beck Depression Inventory (BDI). Positron emission tomographic measurement of 5HT1A receptors was performed with 18F-FCWAY, a highly specific silent antagonist. 3D-T1-weighted MRI was used to correct for structural atrophy. Receptor distribution volume (V) was corrected for plasma tracer free fraction (f1).
There was a significant inverse relation between ipsilateral hippocampal v/f1 and the BDI. For contralateral hippocampus, there was a nonsignificant trend. Patients with BDI > 20 had significantly lower ipsilateral hippocampal V/f1 than patients in the low and medium groups. There was no significant effect of the presence of mesial temporal sclerosis, focus laterality, or gender on the BDI.
Our study shows a relationship between hippocampal 5HT1A binding and depressive symptoms measured by the BDI in patients with epilepsy. The findings parallel results in patients with MDD.
研究颞叶癫痫患者海马5HT1A受体结合与抑郁症状之间的关系。抑郁症在癫痫患者中很常见，并且有报道称原发性抑郁症患者的5HT1A结合减少。
我们研究了45例经发作期视频脑电图记录确诊的颞叶癫痫患者。使用贝克抑郁量表（BDI）评估情绪。用18F-FCWAY（一种高度特异性的非活性拮抗剂）进行正电子发射断层扫描测量5HT1A受体。使用三维T1加权磁共振成像来校正结构萎缩。受体分布容积（V）根据血浆示踪剂游离分数（f1）进行校正。
同侧海马V/f1与BDI之间存在显著的负相关。对于对侧海马，存在不显著的趋势。BDI>20的患者同侧海马V/f1显著低于低分组和中分组患者。内侧颞叶硬化、病灶偏侧性或性别对BDI均无显著影响。
我们的研究表明癫痫患者海马5HT1A结合与BDI测量的抑郁症状之间存在关联。这些发现与重度抑郁症患者的结果相似。
