Montañez Raúl, Navas-Delgado Ismael, Medina Miguel Angel, Aldana-Montes José F, Sánchez-Jiménez Francisca
Department of Molecular Biology and Biochemistry, Centre for Biomedical Research on Rare Diseases, University of Malaga, E-29071 Malaga, Spain.
Cell Immunol. 2006 Dec;244(2):84-6. doi: 10.1016/j.cellimm.2006.12.008. Epub 2007 Apr 17.
After a brief introduction to point out the necessity to advance for a global understanding of the macromolecular interactions occurring during the immune system development and responses, Section 2 will be devoted to analyse the current tools for an automatic location of information on these protein-protein interactions in the web. In the next section (Section 3), we will point out different action lines to improve these tools and, consequently, to increase the efficiency to establish (to understand) the "protein network skeleton" that controls our immune responses. Finally, we will briefly present our current strategy and work to advance towards this goal.
在简要介绍指出有必要进一步全面了解免疫系统发育和反应过程中发生的大分子相互作用之后，第2节将专门分析当前用于在网络中自动定位这些蛋白质 - 蛋白质相互作用信息的工具。在下一节（第3节）中，我们将指出不同的行动方向以改进这些工具，从而提高建立（理解）控制我们免疫反应的“蛋白质网络骨架”的效率。最后，我们将简要介绍我们目前为实现这一目标而采取的策略和开展的工作。
