Pappalardo F, Motta S, Lollini P-L, Mastriani E
Faculty of Pharmacy, University of Catania, Italy.
Cell Immunol. 2006 Dec;244(2):137-40. doi: 10.1016/j.cellimm.2007.03.002. Epub 2007 Apr 17.
We present a further, yet important, step in applying Catania Mouse Model & simulator (SimTriplex) of immune system response to vaccination. In particular we show that, as immune response can induce toxicity, one can calibrate the vaccine administrations in such a way to avoid toxicity effects, keeping immunoprevention from cancer. This result increases the model's potential applications.
我们展示了在应用免疫系统对疫苗接种反应的卡塔尼亚小鼠模型及模拟器（SimTriplex）方面更进一步且重要的一步。特别是我们表明，由于免疫反应可诱导毒性，人们可以通过校准疫苗接种方式来避免毒性作用，同时保持对癌症的免疫预防。这一结果增加了该模型的潜在应用。
