Hirose S, Kobayashi K, Kajikawa K, Sawabu N
Am J Gastroenterol. 1975 Nov;64(5):382-91.
A case of watery diarrhea, hypokalemia and hypercalcemia associated with an islet cell tumor was described. A 62-year old man exhibited frequent watery diarrhea and hypokalemia for two years. He had no peptic ulcer and serum gastrin level was normal. His serum calcium was abnormally high and serum phosphate was lowered. He had secretin-like activity in his plasma. Autopsy revealed a small islet cell tumor in the pancreas and several metastatic masses in the liver. Microscopic examination revealed the tumor cell was not beta, alpha nor D cells. By electron microscopy the secretion granules of the tumor cell resembled those of S, M and T cells. It was not possible to decide which of the tree cell types was responsible for the pancreatic cholera.
描述了一例与胰岛细胞瘤相关的水样腹泻、低钾血症和高钙血症病例。一名62岁男性两年来频繁出现水样腹泻和低钾血症。他没有消化性溃疡，血清胃泌素水平正常。他的血清钙异常升高，血清磷降低。他的血浆中有促胰液素样活性。尸检发现胰腺有一个小的胰岛细胞瘤，肝脏有几个转移瘤。显微镜检查显示肿瘤细胞不是β细胞、α细胞也不是D细胞。通过电子显微镜观察，肿瘤细胞的分泌颗粒类似于S、M和T细胞的分泌颗粒。无法确定这三种细胞类型中的哪一种是导致胰性霍乱的原因。
