通过儿科肠外营养持续输注甲泼尼龙：一项药代动力学动物研究。
Continuous infusion of methylprednisolone via paediatric parenteral nutrition: a pharmacokinetic animal study.
作者信息
Gellis Christophe, Sautou-Miranda Valérie, Bleyzac Nathalie, Jarrige Jean-François, Minet-Quinard Régine, Chopineau Jean
机构信息
Laboratoire de Pharmacie Clinique et Biotechnique, EA2416, Faculté de Médecine-Pharmacie, 28 Place Henri-Dunant, 63000, Clermont-Ferrand, France.
出版信息
Clin Nutr. 2007 Aug;26(4):491-7. doi: 10.1016/j.clnu.2007.02.005. Epub 2007 Apr 17.
BACKGROUND & AIMS: The aim of our study consisted to measure the pharmacokinetic parameters of methylprednisolone administered in a continuous infusion of a paediatric parenteral nutrition mixture for 24h in the rabbit.
METHODS
Fourteen rabbits were split into two groups and assigned a different administration vehicle (all-in-one or two-in-one nutrition mixture). We used USC PACK* pharmacokinetics software to compare the influence of the composition of the paediatric parenteral nutritional solutions on the values of the pharmacokinetic parameters of methylprednisolone.
RESULTS
Neither the steady-state plasma concentrations of methylprednisolone hemisuccinate nor the values of the pharmacokinetic parameters of methylprednisolone differed significantly when administered in two-in-one or all-in-one nutrition mixtures.
CONCLUSIONS
The composition of the nutritional medium had no discernable effect on the bioavailability of methylprednisolone. Neither the speed at which the steady-state plasma concentration was reached, nor the values of the pharmacokinetic parameters of methylprednisolone were significantly modified.
背景与目的
我们研究的目的是测定甲基泼尼松龙在兔体内连续输注24小时的儿科肠外营养混合液中的药代动力学参数。
方法
将14只兔子分为两组，给予不同的给药载体（全合一或二合一营养混合液）。我们使用USC PACK*药代动力学软件比较儿科肠外营养溶液的组成对甲基泼尼松龙药代动力学参数值的影响。
结果
当在二合一或全合一营养混合液中给药时，半琥珀酸甲基泼尼松龙的稳态血浆浓度和甲基泼尼松龙的药代动力学参数值均无显著差异。
结论
营养介质的组成对甲基泼尼松龙的生物利用度没有明显影响。达到稳态血浆浓度的速度和甲基泼尼松龙的药代动力学参数值均未发生显著改变。
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