猫和兔离体小肺动脉缺氧性收缩的差异

Differences in the hypoxic contraction of small isolated pulmonary arteries of cat and rabbit.

作者信息

Bonnet P, Argibay J A, White E, Garnier D

机构信息

Laboratoire d'électrophysiologie et de pharmacologie cellulaires, Parc de Grandmont, Tours, France.

出版信息

J Comp Physiol B. 1991;161(5):543-7. doi: 10.1007/BF00257911.

DOI:10.1007/BF00257911

PMID:1744251

Abstract

In small (less than 300 microns diameter) pulmonary arterial (PA) rings isolated from the cat, hypoxia induced a transient contraction (250 +/- 120 mg, n = 7), whereas in rings of rabbit PA of the same size, hypoxia had no significant effect (n = 19). Precontraction by 40 mmol KCl.1(-1), noradrenaline (NA) 10(-6) mol.1(-1), or histamine (His 10(-5) mol.1(-1)) did not modify this difference between the two species and did not potentiate the hypoxic contraction of small rings of the cat PA. Large rabbit pulmonary arterial segments (300-2000 microns) exhibited no response to hypoxia before precontraction (n = 15). In the presence of procaine (2%) rabbit PA rings (n = 6, small) exhibited no hypoxic contraction. These results in vitro reflect previous in vivo observations.

摘要

从猫身上分离出的小直径（小于300微米）肺动脉（PA）环，缺氧可诱导短暂收缩（250±120毫克，n = 7），而在相同大小的兔肺动脉环中，缺氧无显著影响（n = 19）。用40毫摩尔氯化钾.1（-1）、去甲肾上腺素（NA）10（-6）摩尔.1（-1）或组胺（His 10（-5）摩尔.1（-1））预收缩并未改变这两个物种之间的这种差异，也未增强猫肺动脉小环的缺氧收缩。大的兔肺动脉段（300 - 2000微米）在预收缩前对缺氧无反应（n = 15）。在存在普鲁卡因（2%）的情况下，兔肺动脉环（n = 6，小环）无缺氧收缩。这些体外实验结果反映了先前的体内观察结果。