Imamura M, Block S R, Mellors R C
Am J Pathol. 1975 Dec;81(3):561-74.
Peripheral blood lymphoid cells obtained from nine twin pairs (six monozygotic and three dizygotic) in which one or both twins had systemic lupus erythematosus (SLE) were examined by electron microscopy for the occurrence of two distinctive intracytoplasmic structures-tubuloreticular structures (TRS) and tubular crystalloids (TC). TRS were found in 0.8 to 14.8% of lymphoid-cell cross sections in 9 of 11 twins with SLE and 2 clinically well but serologically abnormal twins. Lymphoid cells of twins both clinically and serologically normal did not exhibit TRS, although their monozygotic or dizygotic SLE-positive counterparts possessed these structures. Thus, the expression of TRS was more consistent with an acquired than inborn trait and appeared to correlate with disease and serologic manifestations of SLE. TC were found in 1.7 to 7.9% of lymphoid-cell cross sections in every twin examined. No correlation was recognized between clinical or laboratory data and the frequency of TC-bearing cells. The significance and the ultrastructural development of TC in the peripheral blood lymphoid cells are briefly discussed.
从9对双胞胎（6对单卵双胞胎和3对双卵双胞胎）获取外周血淋巴细胞，其中一对或双方患有系统性红斑狼疮（SLE），通过电子显微镜检查两种独特的胞质内结构——管网状结构（TRS）和管状晶体（TC）的出现情况。在11例患有SLE的双胞胎中的9例以及2例临床状况良好但血清学异常的双胞胎中，发现TRS存在于0.8%至14.8%的淋巴细胞横断面中。临床和血清学均正常的双胞胎的淋巴细胞未表现出TRS，尽管其单卵或双卵的SLE阳性对应者拥有这些结构。因此，TRS的表达更符合后天获得性而非先天性特征，并且似乎与SLE的疾病和血清学表现相关。在每例接受检查的双胞胎中，发现TC存在于1.7%至7.9%的淋巴细胞横断面中。未发现临床或实验室数据与含TC细胞的频率之间存在相关性。简要讨论了外周血淋巴细胞中TC的意义和超微结构发育。
