Zuban' O N, Iagafarova R K, Vinogradova T I
Urologiia. 2006 Sep-Oct(5):37-40, 45.
A combined, including urodynamic, study was made in 129 patients with abnormal reservoir function of the urinary bladder (UB). Of them, 82 patients had nephrotuberculosis (NT). Cystoscopy was made in 93 patients, endovesical multifocal biopsy of the bladder wall-- in 23. Correction was conducted with alpha-adrenoblocker alfusozine. In NT, sensory functional disorders of UB prevail (60%). The degree of fibrous-inflammatory involvement of the bladder wall by biopsy findings and severity of urodynamic disorders do not correlate (r < 0.03). Miction recovered in 81.5% patients with NT taking alfusozine. Ileocystoplasty (n = 20) was made in treatment failure and total UB fibrosis. Long-term pathogenic action of specific infection on the neuroreceptor system of the UB may cause defects in its activity. Complex urodynamic investigations of the lower urinary tracts in NT patients identify the type of the disorder and help in making choice of pharmacological or surgical correction. Alfusoxine is a drug of choice in UB hypersensitivity.
对129例膀胱储尿功能异常的患者进行了包括尿动力学检查在内的综合研究。其中，82例患有肾结核（NT）。93例患者进行了膀胱镜检查，23例进行了膀胱壁内多点活检。使用α-肾上腺素能阻滞剂阿夫唑嗪进行治疗。在肾结核患者中，膀胱感觉功能障碍占主导（60%）。活检结果显示的膀胱壁纤维炎症累及程度与尿动力学障碍的严重程度无关（r < 0.03）。服用阿夫唑嗪的肾结核患者中，81.5%的患者排尿功能恢复。对于治疗失败和膀胱完全纤维化的患者，进行了回肠膀胱扩大术（n = 20）。特定感染对膀胱神经受体系统的长期致病作用可能导致其功能缺陷。对肾结核患者下尿路进行的综合尿动力学检查可确定疾病类型，并有助于选择药物或手术治疗方法。阿夫唑嗪是治疗膀胱过敏的首选药物。
