新型亲电二氟甲基化试剂。

New electrophilic difluoromethylating reagent.

作者信息

Prakash G K Surya, Weber Csaba, Chacko Sujith, Olah George A

机构信息

Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, CA 90089-1661, USA.

出版信息

Org Lett. 2007 May 10;9(10):1863-6. doi: 10.1021/ol070195g. Epub 2007 Apr 20.

DOI:10.1021/ol070195g

PMID:17444648

Abstract

A new electrophilic difluoromethylating reagent has been developed. The S-(difluoromethyl)diarylsulfonium tetrafluoroborate has been shown to be effective for the introduction of an electrophilic difluoromethyl group into the following nucleophiles: sulfonic acids, tertiary amines, imidazole derivatives, and phosphines. The reagent failed to transfer the difluoromethyl group to phenols, carbon nucleophiles, and primary and secondary amines.

摘要

一种新型亲电二氟甲基化试剂已被开发出来。已证明四氟硼酸S-(二氟甲基)二芳基锍对将亲电二氟甲基引入以下亲核试剂有效：磺酸、叔胺、咪唑衍生物和膦。该试剂未能将二氟甲基转移至酚类、碳亲核试剂以及伯胺和仲胺。