Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France.
Chem Commun (Camb). 2021 Nov 19;57(92):12337-12340. doi: 10.1039/d1cc04737j.
The synthesis of an original electrophilic difluoromethylating reagent was successfully achieved upon a straightforward protocol (3 steps). Like a Swiss army knife, this bench-stable reagent allowed the functionalization of various classes of compounds under mild and transition metal-free conditions. Hence, an efficient and operationally simple tool for the construction of C(sp)-, C(sp)- and -CFSOPh bonds was provided, expanding the chemical space of PhSOCF-containing molecules. Late-stage functionalization of bioactive molecules and the synthesis of PhSOCF- and HCF-analogs of Lidocaine were also successfully achieved.
成功地按照一个简单的方案（三步）合成了一种原始的亲电二氟甲基化试剂。这个试剂就像瑞士军刀一样，在温和且无过渡金属的条件下，能够实现各种类型化合物的功能化。因此，它为构建 C(sp)-、C(sp)-和-CFSOPh 键提供了一个高效且操作简单的工具，扩展了含 PhSOCF 分子的化学空间。此外，还成功地实现了生物活性分子的后期功能化以及 Lidocaine 的 PhSOCF-和 HCF 类似物的合成。
