Fan Jian-Gao, Li Feng, Cai Xiao-Bo, Peng Yong-De, Ao Qing-Hong, Gao Yan
Center for Fatty Liver, Department of Gastroenterology, Shanghai First People's Hospital, Jiaotong University, Shanghai, China.
J Gastroenterol Hepatol. 2007 May;22(5):663-8. doi: 10.1111/j.1440-1746.2007.04892.x.
To evaluate changes in the prevalence rates of ultrasonographic fatty liver (FL) in a specific population.
An analysis of the medical records of BaoSteel Group (Shanghai, China) employees was done to evaluate the prevalence of FL in this population, in which health examinations were performed biennially between 1995 and 2002.
The study reviewed a database of 59 131 employees, of which 27.1% received medical check-ups four times within the study period, 26.6% three times, and 24.0% twice. The prevalence rates of obesity and metabolic disorders were high at baseline and increased significantly with time. The prevalence of ultrasonographic FL increased from 3.87% to 14.04% in the overall population, while there was an increase from 4.44% to 14.64% in men and 1.56% to 11.37% in women over the 6-year study period. Increased rates of FL were also noted, from 25.88% to 51.39%, among patients with elevated serum alanine aminotransferase (ALT) levels (> 40 U/L). The highest overall prevalence rates of FL were found in individuals aged 50-60 years, with all age-associated prevalence significantly higher in males than females.
The prevalence of FL increased rapidly over the study period with increased rates of obesity and metabolic disorders; FL is becoming a major cause of abnormal ALT levels in the specific population.
评估特定人群中超声诊断脂肪肝（FL）患病率的变化情况。
对宝钢集团（中国上海）员工的病历进行分析，以评估该人群中FL的患病率。在1995年至2002年期间，每两年进行一次健康检查。
该研究回顾了59131名员工的数据库，其中27.1%的员工在研究期间接受了4次体检，26.6%接受了3次，24.0%接受了2次。肥胖和代谢紊乱的患病率在基线时较高，并随时间显著增加。总体人群中超声诊断FL的患病率从3.87%增至14.04%，在6年的研究期内，男性患病率从4.44%增至14.64%，女性从1.56%增至11.37%。血清丙氨酸氨基转移酶（ALT）水平升高（>40 U/L）的患者中，FL患病率也有所增加，从25.88%增至51.39%。FL总体患病率最高的是50至60岁的人群，所有与年龄相关的患病率男性均显著高于女性。
在研究期间，随着肥胖和代谢紊乱患病率的增加，FL患病率迅速上升；FL正成为该特定人群ALT水平异常的主要原因。
