Sumbayev V V, Yasinska I M
Medway School of Pharmacy, University of Kent and Greenwich, Kent, UK.
Scand J Immunol. 2007 May;65(5):399-406. doi: 10.1111/j.1365-3083.2007.01919.x.
Recent reports devoted to the field of oxygen sensing outline that signalling molecules such as nitric oxide/nitric oxide derived species as well as cytokines and other inflammatory mediators participate in hypoxic signal transduction. In the present review, we summarize the current knowledge about the role of nitric oxide and reactive nitrogen species (RNS) derived from it in hypoxic signal transduction and particularly in accumulation/de-accumulation of hypoxia inducible factor 1 alpha (HIF-1alpha) protein, which is critical not only for cellular adaptation to low oxygen availability but also for generation of inflammatory and innate immune responses. After brief description of nitric oxide and other RNS as multifunctional messengers we analyse and discuss the RNS-dependent accumulation of HIF-1alpha protein under normoxia followed by discussion of the mechanisms of nitric oxide (NO)-dependent enzyme-regulated degradation of HIF-1alpha protein under low oxygen availability.
近期有关氧感应领域的报告指出，诸如一氧化氮/一氧化氮衍生物质以及细胞因子和其他炎症介质等信号分子参与了缺氧信号转导。在本综述中，我们总结了当前关于一氧化氮及其衍生的活性氮物质（RNS）在缺氧信号转导中的作用的知识，特别是在缺氧诱导因子1α（HIF-1α）蛋白的积累/去积累方面的作用，这不仅对细胞适应低氧可用性至关重要，而且对炎症和先天免疫反应的产生也至关重要。在简要描述一氧化氮和其他RNS作为多功能信使之后，我们分析并讨论了常氧下RNS依赖的HIF-1α蛋白积累，随后讨论了低氧可用性下一氧化氮（NO）依赖的酶调节HIF-1α蛋白降解的机制。
