Kim S-Y, Choi H-B, Yoon H-Y, Choi E-J, Cho B, Kim H-K, Kim Y-J, Kim H-J, Min C-K, Kim D-W, Lee J-W, Min W-S, Kim C-C, Kim T-G
Department of Microbiology and Immunology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Tissue Antigens. 2007 Apr;69 Suppl 1:114-7. doi: 10.1111/j.1399-0039.2006.762_9.x.
Interactions between killer cell immunoglobulin-like receptors (KIRs) and human leukocyte antigen class I ligands influence the development of the natural killer cell repertoire and the responses to infection, cancer, and allogeneic tissue. In this study, the association of KIR genes with acute graft-vs-host disease (GVHD) was investigated in 44 pairs of leukemia patients and their unrelated donors for hematopoietic stem cell transplantation (HSCT). Donors with more than 12 KIR genes showed significantly decreased frequencies of severe acute GVHD compared with donors with less than 11 KIR genes (P < 0.05). The distribution of KIR genotypes was not different between severe and mild acute GVHD in patients and donors, respectively. These results suggest that the number of KIR genes in donors could influence the occurrence of acute GVHD after unrelated HSCT.
杀伤细胞免疫球蛋白样受体（KIR）与人类白细胞抗原I类配体之间的相互作用影响自然杀伤细胞库的发育以及对感染、癌症和同种异体组织的反应。在本研究中，在44对进行造血干细胞移植（HSCT）的白血病患者及其无关供体中，研究了KIR基因与急性移植物抗宿主病（GVHD）的关联。与具有少于11个KIR基因的供体相比，具有超过12个KIR基因的供体发生严重急性GVHD的频率显著降低（P < 0.05）。患者和供体中，重度和轻度急性GVHD之间KIR基因型的分布没有差异。这些结果表明，供体中KIR基因的数量可能影响无关HSCT后急性GVHD的发生。
