Moscoso J, Serrano-Vela J Ignacio, Arnaiz-Villena A
Department of Immunology, The Madrid Regional Blood Center, Universidad Complutense, Madrid, Spain.
Tissue Antigens. 2007 Apr;69 Suppl 1:136-9. doi: 10.1111/j.1399-0039.2006.763_3.x.
The major histocompatibility complex (MHC)-F class Ib locus shows a limited polymorphism, and the function of its mainly intracellular protein is not clear. We have identified human leukocyte antigen (HLA)-F orthologous DNA sequences in Pongidae in order to study the MHC-F gene evolution and its products' function. HLA-F orthologous complementary DNA transcripts are found in chimpanzee and in the new primate species studied (bonobo, gorilla and orangutan). Analyses of the predicted amino acid sequences and their comparison with other primate MHC-F proteins show that MHC-F may be a protein with a typical class I structure and that the key residues of the peptide-binding region are highly conserved in MHC-F in all studied primates species. Thus, MHC-F conservation along the primate evolution suggests an important role in cellular physiology. It is possible that the MHC-F protein could be involved, together with MHC-G and MHC-E, in the natural killer cell activity regulation, although rhesus macaque cannot express complete surface MHC-G orthologue molecules.
主要组织相容性复合体（MHC）-F Ib类基因座表现出有限的多态性，其主要存在于细胞内的蛋白质的功能尚不清楚。我们已经在猩猩科动物中鉴定出人类白细胞抗原（HLA）-F的直系同源DNA序列，以便研究MHC-F基因的进化及其产物的功能。在黑猩猩以及所研究的新灵长类物种（倭黑猩猩、大猩猩和猩猩）中发现了HLA-F直系同源互补DNA转录本。对预测的氨基酸序列进行分析，并将其与其他灵长类MHC-F蛋白进行比较，结果表明MHC-F可能是一种具有典型I类结构的蛋白质，并且在所有研究的灵长类物种中，肽结合区的关键残基在MHC-F中高度保守。因此，MHC-F在灵长类进化过程中的保守性表明其在细胞生理学中具有重要作用。尽管恒河猴不能表达完整的表面MHC-G直系同源分子，但MHC-F蛋白有可能与MHC-G和MHC-E一起参与自然杀伤细胞活性的调节。
