Duquesnoy R J, Claas F H J
Division of Transplantation Pathology, Thomas E. Starzl Transplantation Institute, University of Ptttsburgh Medical Center, Pittsburgh, PA 15261, USA.
Tissue Antigens. 2007 Apr;69 Suppl 1:180-4. doi: 10.1111/j.1399-0039.2006.00766.x.
Under auspices of the 14th International Human Leukocyte Antigen (HLA) and Immunogenetics Workshop, multilaboratory collaborative studies were organized addressing the following projects: (1) identification of structurally defined class I and class II HLA epitopes by human monoclonal antibodies, (2) assessment of the relative immunogenicity of structurally defined donor HLA mismatches in kidney transplantation, and (3) evaluation of the usefulness of structurally based HLA matching in platelet transfusion support of alloimmunized thrombocytopenic patients. This progress report describes a preliminary HLAMatchmaker-based data analysis in each project. The findings support the clinical usefulness of structural HLA matching.
在第14届国际人类白细胞抗原（HLA）与免疫遗传学研讨会的支持下，组织了多实验室合作研究，涉及以下项目：（1）用人单克隆抗体鉴定结构明确的I类和II类HLA表位；（2）评估肾移植中结构明确的供体HLA错配的相对免疫原性；（3）评估基于结构的HLA匹配在同种免疫性血小板减少症患者血小板输注支持中的实用性。本进展报告描述了每个项目中基于HLAMatchmaker的初步数据分析。研究结果支持结构HLA匹配的临床实用性。
